K9 Advantix® II

Item #0040155

$29.99 to $69.99

K9 Advantix® II

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K9 Advantix® II is a once-a-month topical tick, mosquito and flea treatment for dogs and puppies 7 weeks of age or older. Read More

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Featured Advice from Our Experts


Canine Wellness Series - Part 3 - Zoonotic Diseases... What can I catch?

At one time or another, most of us have watched our dogs have a bout of the sniffles or diarrhea. Many of us have wondered if we, too, were at risk of getting sick. Diseases that are passed from animals to humans are zoonotic illnesses. The most well known and most feared zoonotic disease is rabies. Read More...


K9 Advantix® II

Offering broad spectrum protection that not only kills but repels fleas, ticks, and mosquitoes, this convenient once a once-a-month topical treatment is for dogs and puppies 7 weeks of age or older and weighing 4 lb or more. Containing Imidacloprid and Permethrin plus the insect growth regulator Pyriproxyfen, these ingredients work in unison to repel and kill parasites that can potentially carry diseases.

K9 Advantix® II Key Benefits:

  • repels and kills ticks, mosquitos and fleas for up to four weeks
  • repels and kills fleas of all life stages within 12 hours
  • prevents development of fleas for up to four weeks
  • repels biting flies
  • kills chewing lice
  • waterproof
Do not use on cats.

Note: For maximum effectiveness, you should not bathe your pet 48 hours before or after application. The oils of the skin and coat help to distribute the product properly, ensuring that the product will be effective.

View manufacturer and/or label information - Small Dog

View manufacturer and/or label information - Medium Dog

View manufacturer and/or label information - Large Dog

View manufacturer and/or label information - X-Large Dog


  • Brand: Bayer Animal Health
  • Type: Flea & Tick
  • Form: Spot-On

Reviews (20)

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  1. 5.0 out of 5 stars

    "Just once a month"

    All I have to do is remember my Advantix II once a month and it protects my dogs against everything. All the pests including mosquito's. How easy is that???

  2. 5.0 out of 5 stars

    "Best & Safest flea control"

    I've been a Rescue for 40 years. Nothing works better than K9 Advantix (from the original). I won't use anything else!

  3. 5.0 out of 5 stars


    I bought thius exact product at Petsmart for 70 dollatrs. I went to walmart and found exact same thing for 50. I took the petsmart product back now i find thisfor 29 . thats worth ordering for.

  4. 5.0 out of 5 stars


    The best flea prevention treatment by far!! I have 2 dogs and a cat. Advantage keeps them all completely flea and tick free!

  5. 5.0 out of 5 stars

    "advantix 2"

    I love it on my dogs we live in the country with lots of trees, and bushes, I don't have to worry, about anything.

  6. 5.0 out of 5 stars

    "Doesn't work"

    Didn't do what it said. Didn't kill the fleas or control them at all stages. My poor dog has rubbed the hair off her back where it was applied....switching to something else.

  7. 5.0 out of 5 stars

    "Shihtzu Man"

    Best product on the market.

  8. 5.0 out of 5 stars

    "Worth Every Penny..."

    K9 Advantix II is worth every single penny, and then some. Since moving to Missouri, I've always used Frontline Plus. It's an OK product but it does NOT repel anything and I was constantly finding ticks all over Chico (my Shih Tzu) and they were attaching themselves to him. Every single time he would go outside I found ticks that were very much alive. Too creepy for me! So this year I was determined to try something new, that's how I found out about K9 Advantix II. It works like a charm!!Since September of 2012 I have not had one single tick on my dog, not one. This product also repels and kills: mosquito, fleas and other insects. It's a little more expensive but it's worth it. We live in a very wooded area that is prime for ticks so having a product like this is a awesome. I highly recommend it to anyone who is looking to replace FrontLine Plus. I don't usually get so excited about products but I felt I had to share my personal experience. Good luck and I hope you love K9 Advantix II as much as I do.

  9. 5.0 out of 5 stars

    "Wonderful Product"

    "We had moved into a new area almost a year ago. At our former location, we never had a real problem with fleas. That changed this year! Having 7 dogs to treat, I tried the ""cheap"" way. I bought the ""groomer's pack"" which was a waste of money. I tried sprays, shampoos then THIS! I purchased the 55 lb. and over package. Two tubes treated all of my doxies (6) and my pug. I treated them in the evening. The next morning I changed their bedding. I couldn't believe all of the dead fleas on their blankets! This stuff works and I will NEVER waste my time and money on anything else!"

  10. 5.0 out of 5 stars

    "The BEST flea and tick repellent "

    When our oldest dog was a six month old puppy, we tried Frontline at the veterinarian?ÇÖs recommendation. It was a disaster. The medication caused his skin to become so irritated that he developed a sore on the back of his neck. To make matters worse, the Frontline was ineffective. We all had to live with fleas for two or three weeks, while his sore healed enough to permit us to apply an alternative flea and tick medication. During that time, we did a lot of research on similar medications. Everyone recommended K9 Advantix II. We tried it and it worked wonderfully. We love that it is waterproof. And, each application lasts five to six weeks. Plus, it is the only medication we found, which can be used on both of our dogs, who weigh between twenty- one and fifty- five ponds. Our oldest dog has never had any problems with this medication and it has been equally effective on our other dog. We will NEVER use another flea and tick medication.

  11. 5.0 out of 5 stars

    "The best product hands down."

    We live in sunny south Florida where we have fleas year round. Our dog has allergies especially to fleas. This is the ONLY product that keeps them off of her so she stays comfortable. She gets bathed at least twice a week for the pollen and still this stuff works on the fleas for a whole month.

  12. 5.0 out of 5 stars

    "THE BEST!!!"


  13. 5.0 out of 5 stars

    "Good Stuff"

    Used Frontline then when moved to Memphis it seemed to not hold up against whatever different bugs/fleas/etc here. Switched to this and have seen great improvement in the fleas dander and itching in my cocker. Frontline wasn't repelling the fleas

  14. 5.0 out of 5 stars

    "The Best Product Yet"

    I used Bio-spot for a couple years 'til it stopped working. Then tried Frontine and it never worked. I've used Advantix since it was first marketed on both my dogs and cats (cat formula of course) and it hasn't stopped working since. I apply it to the dogs every 1.5 - 2 months. I no longer use it on the cats since they've been indoors only as the dogs treatments also seem to keep the cats flea free. When the cats start scratching I know it's time to treat the dogs again. I have had no fleas in the house or on the animals since using Advantix and the ticks don't even latch on. Wouldn't use anything else!

  15. 5.0 out of 5 stars


    I had used Bio-spot for YEARS with NO problems....This past summer, it did not work at all & had to run out to local pet store & was recommended this product. It worked like a charm!! Thank goodness!! I will keep using this product because it works for me!!

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