I have an aging Great Dane who loves to chew on her Nylabone Flexible. She's a senior so she doesn't chew as dilligently as she used to and this is perfect for satisfying her occasional chewing urgers. We call it her pacifier because she will sometimes gnaw on it until she falls asleep.
I don't recommend these for more aggressive chewers, as our young APBT mix got it away from the dane one time and tore chunks off of it, but for the lighter chewer, it's perfect.